Tuesday, February 1, 2011

Antivirals, including aciclovir, valaciclovir and famciclovir are safe for baby's first trimester of pregnancy.

Infections with herpes simplex and herpes zoster are relatively frequent and are treated with antivirals, including aciclovir, valaciclovir and famciclovir. Until recently it was believed that the safety of these preparations during the first trimester of pregnancy is insufficient documented.
Exposure to aciclovir or valaciclovir in the first trimester of pregnancy is not associated with increased risk of serious birth defects, according to results of a major study published in the Journal of the American Medical Association.
In the present study were included 837 795 live births babies between 1 January 1996 and September 30, 2008
Serious puerperal effect was found in 40 children (2.2%) of 1804 infants born to mothers who used aciclovir, valaciclovir and famciclovir in the first trimester of pregnancy. This percentage did not differ significantly from 2.4% in children of mothers unexposed to these agents.
This study supports the safety of the above antivirals in the first trimester of pregnancy. Since acyclovir is best studied agent, it must be an agent of choice in early pregnancy.
In an accompanying editorial, Dr. James L. Mills and Dr. Tonia C by the National Institute of Health noted that due to a number of shortcomings study does not meet the key question is whether aciclovir teratogen.

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